Select a product to learn what it is, what research has explored, and how it may relate to weight-management or body-composition goals.

What Semaglutide Is

Semaglutide is a GLP-1 receptor agonist that works with pathways involved in appetite, fullness, digestion, and blood-sugar regulation.

How It May Support Weight Management

It may help reduce appetite, increase feelings of fullness, and make it easier for some people to reduce calorie intake while building sustainable nutrition and lifestyle habits.

What Research Has Found

Human clinical trials have found meaningful average weight reduction in adults with overweight or obesity when once-weekly semaglutide was combined with lifestyle support. Results vary, and some weight regain may occur after treatment is stopped.

Available Options

The Well offers both Semaglutide + B12 and a lyophilized Semaglutide option. Multiple strengths and formulations are available through the shop.

Consultation and Instructions

Some Semaglutide products require a licensed-provider consultation. Preparation, dosing, storage, and administration instructions must match the exact product and concentration purchased.

Important Considerations

Possible side effects include nausea, vomiting, diarrhea, constipation, and abdominal discomfort. Prescription eligibility is determined by the licensed provider when required.

Starting at $60

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What Tirzepatide Is

Tirzepatide is a dual GIP and GLP-1 receptor agonist. It works with hormone pathways involved in appetite, fullness, digestion, blood-sugar regulation, and energy balance.

How It May Support Weight Management

Tirzepatide may reduce appetite, increase feelings of fullness, and help some people lower their overall calorie intake. Its dual-action mechanism may also support blood-sugar and metabolic regulation as part of a broader weight-management plan.

What Research Has Found

Large human clinical trials in adults with overweight or obesity have found substantial average weight reduction with once-weekly tirzepatide when combined with nutrition and lifestyle support. Results vary by person, dose, treatment duration, and adherence. Weight regain may occur after treatment is discontinued.

Available Options

The Well currently offers Tirzepatide + B12, Tirzepatide + B3, and a lyophilized Tirzepatide option. Multiple strengths and concentrations are available through the shop. The product pages should remain the source for current formulations, pricing, and availability.

Consultation and Instructions

Some Tirzepatide products require consultation with a licensed provider. Preparation, dosing, storage, and administration instructions must match the exact formulation, concentration, and vial received. Product-specific directions are available through the appropriate secure portal or dispensing team.

Important Considerations

Possible side effects include nausea, vomiting, diarrhea, constipation, reduced appetite, and abdominal discomfort. Tirzepatide is not appropriate for everyone. Prescription eligibility and individualized dosing decisions are made by the licensed provider when required.

Starting at $85

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What Retatrutide Is

Retatrutide is an investigational peptide designed to activate three metabolic hormone receptors: GIP, GLP-1, and glucagon. Researchers are studying this triple-action mechanism for its potential effects on appetite, energy balance, blood-sugar regulation, and body weight.

How It May Relate to Weight Management

Its three-receptor activity is being studied for reducing appetite, increasing fullness, and influencing how the body uses and expends energy. These combined effects may help explain the substantial weight reductions observed in clinical research, but individual outcomes and long-term safety are still being evaluated.

What Research Has Found

In a Phase 2 trial involving adults with obesity, once-weekly retatrutide produced dose-dependent average weight reductions over 48 weeks. The highest-dose group had an average reduction of approximately 24% from baseline. Gastrointestinal effects, including nausea, diarrhea, and vomiting, were among the most common adverse events. Phase 3 studies are ongoing.

Available Option

The Well currently lists a lyophilized Retatrutide product. The linked product page currently displays a 10 mg option at $250, with more options also appearing in the related-product listings. Current strength, pricing, and availability should always be confirmed directly in the shop.

Consultation and Instructions

Preparation, reconstitution, storage, dosing, and administration information must match the exact vial received and should be accessed through the secure portal or supplying team. Do not apply instructions from Semaglutide, Tirzepatide, or a different Retatrutide vial strength.

Important Considerations

Retatrutide remains investigational and is not FDA-approved. Its long-term safety and effectiveness have not yet been established, and ongoing Phase 3 studies are evaluating it in obesity and related conditions. Anyone considering an investigational product should understand that its evidence and regulatory status differ from approved prescription weight-management medications.

Starting at $250

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What Tesamorelin Is

Tesamorelin is a synthetic analog of growth hormone–releasing hormone. It stimulates the pituitary gland to release more of the body’s own growth hormone, which can influence fat distribution, body composition, and metabolism.

How It May Relate to Weight Management

Tesamorelin is not primarily an appetite suppressant and is not considered a general weight-loss medication. Its relevance is more specific to visceral fat—the deeper abdominal fat stored around internal organs—and overall body-composition goals.

What Research Has Found

Human clinical trials in adults with HIV-associated lipodystrophy found meaningful reductions in visceral abdominal fat, including reductions of roughly 15%–18% in several studies. Research has also reported modest reductions in liver fat and improvements in some body-composition measures. These findings come from a specific clinical population, so they should not be presented as proof of general weight-loss effects in everyone.

Available Options

The Well currently offers lyophilized Tesamorelin in 5 mg and 10 mg vial options. The product pages should remain the source for current strength, pricing, and availability.

Consultation and Instructions

Preparation, reconstitution, storage, dosing, and administration instructions must match the exact vial strength purchased. Customers should use the secure portal or supplying team for product-specific instructions.

Important Considerations

Tesamorelin’s FDA-approved use is specifically to reduce excess abdominal fat in adults with HIV-associated lipodystrophy; it is not approved as a general weight-loss treatment. It can raise IGF-1 levels and may affect blood sugar, fluid retention, joints, and injection sites. It is not appropriate for everyone.

Starting at $85

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What MOTS-c Is

MOTS-c is a naturally occurring mitochondrial-derived peptide involved in cellular energy signaling and metabolic regulation. It is being studied for possible effects on glucose use, insulin sensitivity, exercise response, and metabolic health.

How It May Relate to Weight Management

MOTS-c is not an appetite suppressant. Its possible connection to weight management is through metabolic function—particularly how cells use glucose and respond to insulin. That may make it of interest to people focused on metabolic health, body composition, and energy utilization.

What Research Has Found

Animal studies found that MOTS-c improved insulin sensitivity and helped prevent diet-induced obesity and metabolic dysfunction. Human evidence is still developing: a Phase 2a trial is currently evaluating whether investigational MOTS-c can improve insulin sensitivity in adults with prediabetes and overweight or obesity. Direct human weight-loss benefits have not yet been established.

Available Option

The Well currently offers MOTS-c 10 mg (3 mL), lyophilized. The product page should remain the source for current pricing and availability.

Consultation and Instructions

Preparation, reconstitution, storage, dosing, and administration instructions must match the exact vial received. Customers should use the secure portal or supplying team for product-specific guidance.

Important Considerations

MOTS-c remains investigational and is not FDA-approved for weight loss, insulin resistance, or any other medical condition. FDA has also identified compounded MOTS-c as potentially presenting immunogenicity concerns for certain routes of administration, so it should not be described as proven or risk-free.

Starting at $105

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What IGF-1 LR3 Is

IGF-1 LR3 is a modified, longer-acting form of insulin-like growth factor 1. IGF-1 plays an important role in muscle growth, recovery, nutrient use, and maintaining lean tissue.

How It May Relate to Weight Management

IGF-1 LR3 is generally explored for body-composition support rather than appetite reduction. Its potential appeal is helping support lean tissue, recovery, and nutrient utilization—areas that may be especially relevant during calorie reduction, strength training, or other body-recomposition efforts.

What Research Has Explored

Research has examined IGF-1 signaling for its role in skeletal-muscle growth and protein metabolism. IGF-1 LR3 itself has mainly been studied in laboratory and animal models, where researchers have explored effects on nitrogen retention, body weight, and nutrient partitioning. Human research specifically establishing IGF-1 LR3 for weight loss remains limited.

Available Option

The Well currently offers lyophilized IGF-1 LR3. Visit the product listing for the current vial strength, price, testing information, and availability.

Consultation and Instructions

Preparation, storage, and administration instructions should always match the exact product and vial received. Product-specific guidance is available through the secure customer portal or supplying team.

Important to Know

IGF-1 LR3 is better viewed as a lean-tissue and body-composition option than as a direct fat-loss or appetite-control product. Results may vary, and the available evidence is less developed than it is for established weight-management medications.

Starting at $120

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